FROM SEIZURES TO WOUNDS: THE POTENTIAL OF PHENYTOIN IN TRAUMATIC WOUND MANAGEMENT

Objective: Phenytoin is a medication primarily used to treat seizures, but it has been discovered have the potential for wound healing due its ability increase collagen production, promote new blood vessel growth, reduce inflammation, fight infections, and encourage skin growth. These effects are particularly useful chronic wounds like pressure ulcers, diabetic traumatic wounds, venous ulcers. Methods: This two-year prospective study conducted between January 2020 December 2022 at Government General Hospital in Kurnool. A was on 60 patients with dividing them into two groups. One group received topical phenytoin dressing, while other normal saline dressing. The compared surface area, granulation tissue percentage, pain ratings visual analog scale, time groups day 14 21. Results: On 0, cases controls had similar areas (62.17±25.74 cm2 62.14±21.57 cm2, respectively) VAS scores (8.81±1.22 8.88±1.52). By 14, significantly smaller (41±32.32 cm2), higher percentage of (75.56±7.30%), lower (4.57±1.78) (53.28±25.33 58.45±7.01%, 6.32±1.02, respectively). 21, even (28.3±31.75 (93±3.46%), (2.78±0.42) (40.34±34.23 72.56±5.05%, 4.82±1.27, shorter (22.76±7.28 d) (32.64±9.31 d). negative cultures were found 80% 50% control group, statistically significant difference (P-value<0.05). Conclusion: Topical dressing positive by increasing rate formation, providing better relief, shortening time. It be safe, effective, cost-effective option various mechanisms. highlights significance treating limited access expensive wound-healing medications.